In a large skillet over medium heat, add the ground beef. Season with salt, black pepper, garlic powder, and onion powder. Cook until browned and fully cooked, about 6-8 minutes. Drain excess fat and set aside to cool slightly.
In a large bowl, combine the chopped romaine lettuce, cherry tomatoes, dill pickles, shredded cheddar cheese, and diced red onion.
Add the cooked ground beef to the salad mixture and toss gently to combine.
Drizzle the Thousand Island dressing over the salad and toss again until everything is evenly coated.
Serve immediately or refrigerate for up to 30 minutes to allow flavors to meld.