Preheat your oven to 225°F (110°C). Line a baking sheet with parchment paper.
In a large bowl, toss the zucchini slices with salt, pepper, garlic powder, and onion powder. Let them sit for about 10 minutes to draw out moisture.
Pat the zucchini slices dry with paper towels to remove excess moisture.
In one bowl, place the beaten egg. In another bowl, combine the breadcrumbs and Parmesan cheese.
Dip each zucchini slice into the egg, then coat it with the breadcrumb mixture, pressing gently to adhere.
Arrange the coated zucchini slices in a single layer on the prepared baking sheet. Lightly spray or drizzle them with cooking spray or olive oil.
Bake in the preheated oven for 1 to 1.5 hours, flipping halfway through, until the chips are golden and crispy.
Remove from the oven and let cool for a few minutes before serving.