In a large bowl, combine the flaked salmon, breadcrumbs, onion, bell pepper, mayonnaise, egg, Dijon mustard, Worcestershire sauce, garlic powder, black pepper, and salt. Mix until well combined.
Shape the mixture into patties, about 2-3 inches in diameter. You should have approximately 8 patties.
Heat the vegetable oil in a large skillet over medium heat. Once hot, carefully place the patties in the skillet, cooking in batches if necessary to avoid overcrowding.
Fry the patties for 3-4 minutes on each side, or until golden brown and crispy. Remove from the skillet and drain on paper towels.
Serve warm with lemon wedges on the side.