In a large bowl, combine the ground turkey, garlic powder, onion powder, smoked paprika, salt, and black pepper. Mix until well combined, then form into 12 small patties.
Heat olive oil in a large skillet over medium heat. Add the turkey patties and cook for about 5-6 minutes on each side, or until they are cooked through and reach an internal temperature of 165°F.
While the patties are cooking, prepare the avocado sauce. In a small bowl, mash the avocado and mix in the Greek yogurt, lime juice, salt, and garlic powder until smooth.
Once the patties are done, remove them from the skillet and let them rest for a few minutes.
Assemble the sliders by placing a turkey patty on each slider bun, topping with shredded lettuce, a slice of tomato, and a generous dollop of avocado sauce.
Serve immediately and enjoy!